Manchester United look to retake top spot in the Premier League when they take on Hull as others concentrate on the FA Cup
Only one Premier League match takes place this weekend as Hull travel to Manchester United with the hosts knowing they can overhaul Arsenal and go back to the top of the league if they win.
Rio Ferdinand returns to the Manchester United team for the first time since October but striker Dimitar Berbatov may miss out giving youngster Mame Biram Diouf the chance to make his first start for the club.
Elsewhere there are 12 FA Cup fourth round ties featuring Premier League clubs and several possibilities for a giant killing.
Arsenal face a tough task away at Stoke with Arsene Wenger likely to field a weakened team, which is likely to include Sol Campbell while Stoke will be fairly strong as they have no midweek league game to worry about.
Fulham travel to League Two side Accrington Stanley with a few defensive problems having lost Paul Konchesky and John Pantsil to injury.
Manchester United's conqueror's Leeds travel to Tottenham who are likely to be at full strength as Harry Redknapp looks for another Wembley final.
Reading dispatched of Liverpool in round three and host Burnley this weekend with Brian Laws being able to pick from virtually a fully fit squad.
Aston Villa are expected to make several changes from the team that reached the Carling Cup final in midweek following that epic 6-4 win over Blackburn.
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