Liverpool suffer fifth defeat, are reduced to nine men and see Chelsea, United and Arsenal win big
Bobby Zamora, Erik Nevland and Clint Dempsey were all on target as Fulham ran out 3-1 winners over Liverpool at Craven Cottage.
Zamora opened the scoring, tapping in Damien Duff's cross before Fernando Torres levelled matters for the visitors, volleying home a loose ball.
Nevland skilfully flicked Fulham back into the lead before two of Liverpool's back-four saw red and then Dempsey tapped in a third goal to seal the win from Nevland's cross.
Chelsea remained top of the league and continued their astounding run of results with a 4-0 win at Bolton, meaning they have now notched up 17 goals without reply in their last four games.
The league leaders were rampant in the first half but the break-through did not come until right on half time when Didier Drogba was fouled in the box and Frank Lampard scored the resulting spot kick.
Deco excellently clipped in a second, via a deflection of a defender, following a lay-off from Nicolas Anelka.
As the deflection came after Deco's strike then the last clean pass to the goalscorer still came from Anelka and so he retains the two Fantasy League points.
Ricardo Carvalho's cross created Chelsea's third as Branislav Ivanovic and Bolton defender Zat Knight between them bundled the ball into the net.
The goal has been officially credited as a Knight own goal and as the touch from Knight came instantly after Ivanovic had made contact with the ball, the benefit of doubt was given and a double assist was awarded to Carvalho and Ivanovic.
Drogba added a superbly worked fourth in stoppage time, Deco chested the ball to Lampard who flicked it into Drogba's path and the Ivorian finished first-time.
The touch from Lampard did not change the direction or horizontal speed of Deco's chest pass and so a double assist was given.
Manchester United kept pace with their rivals, ahead of the meeting between the top-two next weekend, with a 2-0 win over Blackburn in the Saturday tea-time kick off.
Dimitar Berbatov expertly opened the scoring when he flicked Patrice Evra's effort up to himself before swivelling and firing home on the volley.
Wayne Rooney sealed the points late-on when he got across the front of his marker and diverted Anderson's low cross into the corner of the net.
In the day's early kick-off, Arsenal ran out comfortable 3-0 winners over Tottenham in the North London derby.
Two goals in two minutes sank the visitors, firstly Robin van Persie steered Bacary Sagna's cross in at the near post and then from the restart the ball was hit against van Persie and fell to Cesc Fabregas who ran from halfway, evaded two challenges and fired home.
Van Persie sealed the points when he added a third when Bacary Sagna's cross evaded the reach of Gomes and the Dutchman tapped home.
Portsmouth picked up their first league home win of the season, and in convincing fashion, with a 4-0 victory over Wigan.
Aruna Dindane opened the scoring, dinking the ball over the keeper, after receiving a pass from Michael Brown before turning provider sending Frederic Piquionne clear to double the lead.
Dindane added his second of the match from close range after being found by Kanu before the Nigerian was brought down in the box allowing Dindane to complete his hat-trick from the spot.
Burnley got back to winning ways on home soil with a 2-0 win over struggling Hull.
Graham Alexander netted both goals, first from the spot after Tyrone Mears was fouled in the box, and then with an excellent low drive after being found by Kevin McDonald.
Two sides who were closest to the top-four last season, Everton and Aston Villa, played out a 1-1 draw at Goodison Park.
Diniyar Bilyaletdinov fired Everton in front after Yakubu inadvertently kicked the ball against his other foot and it fell nicely to the Russian.
Substitute John Carew levelled right after the break with his first touch when Gabriel Agbonlahor's deflected shot was parried and fell kindly for the big Norwegian.
Because the deflection changed the direction of Agbonlahor's shot before it was parried, no assist was given.
West Ham threw away a two goal lead at the Stadium of Light, a week after coming back from 2-0 down against Arsenal.
Guillermo Franco opened the scoring with his first Premier League goal when he turned in Jack Collison's cross and Collison laid on the second for Carlton Cole with a slide-rule pass.
Andy Reid fired in a stunning free-kick to reduce the arrears and then Kieran Richardson bundled home a deflected cross at the far post to level the match.
The goal has been reviewed by the Fantasy League assists panel, who ruled that the deflection after Darren Bent's cross significantly changed the horizontal speed of the ball as it travelled towards the penalty area. No assist has been awarded to Bent as the deflection allowed Richardson to receive the ball in a position at the far post where he would not otherwise have been able to receive it, had the ball continued its speedy travel unimpeded.
Stoke were also 2-0 up only to be pegged back by Wolves thanks to a Jody Craddock brace.
George Elokobi turned Matthew Etherington's cross into his own net before Etherington volleyed in a loose ball from the edge of the box to double the lead.
Craddock pulled one back at the far post when Nenad Milijas' free-kick was flicked on in the centre by Christophe Berra and then he headed the equaliser from a Milijas corner.
Finally, Birmingham and Manchester City played out a 0-0 draw in the only game to be played on Sunday.