Defoe sidelined by hamstring injury
Tottenham have been hit by the news that Jermain Defoe faces a few weeks on the sidelines with a hamstring injury.
Ryan Shawcross is expected to return to the Stoke starting 11 to face Spurs, despite suffering an ankle injury during the week.
Arsenal could have Cesc Fabregas available for the visit of West Ham on Saturday evening, provided the skipper comes through a late fitness test.
Aston Villa are sweating on the fitness of top-scorer Gabriel Agbonlahor after he limped off during the midweek win over Wigan with a groin injury.
Manchester United have been boosted by the return of four players ahead of their clash with rivals Liverpool on Sunday.
Ryan Giggs, Rafael and Jonny Evans are all in contention after returning to training and Owen Hargreaves made a long awaited comeback appearance for the reserves on Thursday night.
Fabio Aurelio could be a surprise inclusion for Liverpool after making a quicker than expected recovery from a thigh problem but there is a concern over the fitness of Alberto Aquilani, who has had a virus all week.
New Hull boss Iain Dowie will be without George Boateng and Kamil Zayatte when he takes charge of the Tigers for the first time at Portsmouth on Saturday.
Wigan look set to be without Charles N'Zogbia for Saturday's visit of Burnley after the winger picked up an ankle injury during Tuesday night's defeat against Aston Villa.
Finally, Roy Hodgson may have masterminded a famous win over Juventus in midweek, but that won't stop him making changes for the visit of Manchester City on Sunday with Danny Murphy, Jonathan Greening and Nicky Shorey set to return.
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