Newcastle will be without two first choice defenders when they take on Cardiff and their new manager Ole Gunnar Solskjaer. Meanwhile, Mesut Ozil could return from a shoulder injury for Arsenal to face North London rivals Tottenham.
Supersub Oscar started the New Year in the best possible fashion by topping the Fantasy League points charts after inspiring Chelsea to victory at Southampton. The Brazilian playmaker had a part in all three goals
Attacking midfielder Kevin Nolan was the top scoring player at the weekend with seven points from the entertaining 3-3 draw between West Ham and West Brom. Nolan played a part in all three goals, bagging one goal and two assists.
Welsh wizard Aaron Ramsey will miss the rest of the festive period after suffering a thigh injury in the win over West Ham on Boxing Day. The Arsenal midfielder will sit out the trip to Newcastle on Sunday.
The unstoppable Luis Suarez was the highest scoring player once again this weekend with eight points. Suarez played a part in all three of the goals Liverpool put past Cardiff.
Manchester City will be without star striker Sergio Aguero for up to eight weeks because of a calf injury. The Argentine attacker picked up the problem during last week's comprehensive win over Arsenal.
Striker supreme Luis Suarez was the top scoring player again at the weekend with a titanic 12 points against Tottenham. Liverpool put five past Spurs at White Hart Lane and stand-in captain Suarez was involved in every goal.
Liverpool captain Steven Gerrard will miss Sunday's trip to Tottenham with a hamstring problem and could be out until February. The influential midfielder suffered the injury during the 4-1 win over West Ham.
Wayward Manchester United will be without Wayne Rooney when they host Newcastle in Saturday's early kick-off. Robin van Persie remains a doubt for the struggling reigning champions and Shinji Kagawa is ill.
Everton defender Bryan Oviedo was the leading points scoring player at the weekend after bagging a Fantasy League grand slam in the 4-0 demolition of Stoke. The Costa Rican took full advantage of Leighton Baines' absence in his second ever league start for the Toffees.
Manchester City duo Sergio Aguero and Jesus Navas both scored eight points in the 6-0 destruction of Tottenham. The skilful twosome bagged two goals and an assist apiece as Spurs were brushed aside.
Following the half-time interval it's time to get down to business for the second period. The Insider Eye casts its studious gaze over the pick of this weekend's fixtures, offering some statistics and insight that will aid your fantasy football cause.